Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Ethoxyaniline → [5-Chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-(3-ethoxy-phenyl)-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Ethoxyaniline | HCID 12120 | — |
| 반응물 | 3-chloro-2-(4-chloro-phenyl)-2H-indazole | HCID 2776903 | — |
| 반응물 | 3,5-Dichloro-2-(4-chlorophenyl)-2H-indazole | HCID 13143684 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | [5-Chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-(3-ethoxy-phenyl)-amine | HCID 66905404 | — |
반응 단계
In analogy to the procedure described in example 4.1, a mixture of 3,5-dichloro-2-(4-chloro-phenyl)-2H-indazole and 3-chloro-2-(4-chloro-phenyl)-2H-indazole was reacted with 3-ethoxy-phenylamine ([621-33-0]) in N-methyl 2-pyrrolidone for 4 d at 175° C. in a sealed tube to give the title compound after purification by column chromatography (silica gel, iPrOAc/heptane) as yellow foam. MS: m/e=398.1 [M+H+].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08153663B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-a64b007b2b2c4ed0acaeb08f703d1a16 |
| 출처 메모 | uspto-grants-2012_04 |