N-methyl-2-pyrrolidone → N-((R)-1-(2-Fluoro-5-methyl-4-(methylsulfonamido)phenyl)ethyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydroquinoline-6-carboxamide

반응식

Cl.[NH2:2][C@@H:3]([C:5]1[C:10]([F:11])=[CH:9][C:8]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])=[C:7]([CH3:17])[CH:6]=1)[CH3:4].F[P-](F)(F)(F)(F)F.C[N+](C)=C(N(C)C)ON1C2N=CC=CC=2N=N1.[F:42][C:43]([F:58])([F:57])[C:44]1[CH:53]=[CH:52][C:51]2[CH2:50][CH:49]([C:54](O)=[O:55])[CH2:48][CH2:47][C:46]=2[N:45]=1.C(N(CC)C(C)C)(C)C.CN1CCCC1=O>>[F:11][C:10]1[CH:9]=[C:8]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])[C:7]([CH3:17])=[CH:6][C:5]=1[C@H:3]([NH:2][C:54]([CH:49]1[CH2:48][CH2:47][C:46]2[N:45]=[C:44]([C:43]([F:58])([F:42])[F:57])[CH:53]=[CH:52][C:51]=2[CH2:50]1)=[O:55])[CH3:4]