Hydrochloric Acid → Benzo[b]thiophen-2-amine hydrochloride
반응식
C(OC(=O)[NH:7][C:8]1[S:12][C:11]2[CH:13]=[CH:14][CH:15]=[CH:16][C:10]=2[CH:9]=1)(C)(C)C.[ClH:18]>O1CCOCC1>[ClH:18].[S:12]1[C:8]([NH2:7])=[CH:9][C:10]2[CH:16]=[CH:15][CH:14]=[CH:13][C:11]1=2참가 물질
4
실험 절차
Compound 1-B (1.45 g, 5.81 mmol) was added to a solution of HCl in dioxane (4 N, 20 mL), and the mixture was stirred at rt until all the starting material was consumed. The mixture was diluted with diethyl ether, the product collected by filtration, and washed with diethyl ether, to afford compound 1-C as an off-white solid (0.89 g, 83%). 1H-NMR (DMSO-d6): δ 6.43 (s, 1H), 6.8-7.2 (br s, 3H) superimposed on 7.05 (m, 1H) and 7.20 (m, 1H), 7.45 (d, 1H), 7.66 (d, 1H); MS: m/z 150.1 (MH+).
후처리
- customwas consumed
- additionThe mixture was diluted with diethyl ether
- filtrationthe product collected by filtration
- washwashed with diethyl ether
출처 및 근거
- ORD 기록
- ord-95777b88e7c545408d7c862013dabda4
- 출처 데이터셋
- uspto-grants-2012_04
- 특허 번호
- US08153682B2
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