Sodium Hydroxide → thieno[2,3-b]pyridine-2-carboxylic acid

HRID 1691555

반응식

HRID 1691555 반응식
C[O:2][C:3]([C:5]1[S:13][C:8]2=[N:9][CH:10]=[CH:11][CH:12]=[C:7]2[CH:6]=1)=[O:4].[OH-].[Na+]>CO.O>[S:13]1[C:8]2=[N:9][CH:10]=[CH:11][CH:12]=[C:7]2[CH:6]=[C:5]1[C:3]([OH:4])=[O:2]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 19007380Methyl thieno[2,3-b]pyridine-2-carboxylate

생성물 1

HCID 7162095thieno[2,3-b]pyridine-2-carboxylic acid수율 78%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a solution of compound 147-B (0.508 g, 2.63 mmol) in a mixture of MeOH (15 mL) and H2O (3 mL) was added 3N NaOH (1.9 mL, 5.66 mmol) and the reaction mixture was stirred at ambient temperature for 5 h. The solvent was evaporated under reduced pressure, the residue dissolved in H2O, and acidified with 1N HCl. The precipitate was filtered, washed with H2O, and dried under vacuum to afford compound 147-C as a white solid (0.366 g, 78%). MS: m/z 180.0 (MH+).

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. dissolutionthe residue dissolved in H2O
  3. filtrationThe precipitate was filtered
  4. washwashed with H2O
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-f990995312394c4c8c92e046df7071f9
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08153682B2

연결된 노트

불러오는 중…