Sodium Hydroxide → HCID 59302986, 화합물

HRID 1692143노트

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HRID 1692143 반응식
C[O:2][C:3](=[O:32])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][S:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:16][CH:15]=2)(=[O:13])=[O:12])=[C:6]([C:24]2[N:28]([CH3:29])[C:27]([CH2:30][CH3:31])=[N:26][N:25]=2)[CH:5]=1.[OH-].[Na+]>C1COCC1>[C:20]([C:17]1[CH:18]=[CH:19][C:14]([S:11]([NH:10][C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:32])=[O:2])=[CH:5][C:6]=2[C:24]2[N:28]([CH3:29])[C:27]([CH2:30][CH3:31])=[N:26][N:25]=2)(=[O:12])=[O:13])=[CH:15][CH:16]=1)([CH3:23])([CH3:22])[CH3:21]

참가 물질

4

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HCID 14798Sodium HydroxideHCID 59302970HCID 59302970, 화합물

생성물 1

HCID 59302986HCID 59302986, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
60 °C

실험 절차

A 10 mL scintillation vial was charged with 4-(4-tert-butyl-benzenesulfonylamino)-3-(5-ethyl-4-methyl-4H-[1,2,4]triazol-3-yl)-benzoic acid methyl ester (20 mg, 0.044 mmol) and 3 M NaOH (aq)/THF (1:3) (1.5 mL). The reaction was heated to 60° C. and stirred overnight. The following day, the volatiles were removed in vacuo to about 200 μL at which point the solution was purified by preparative TLC to afford 4-(4-tert-butyl-benzenesulfonylamino)-3-(5-ethyl-4-methyl-4H-[1,2,4]triazol-3-yl)-benzoic acid as a light yellow solid: MS (ES) M+H expect 443.2, found 443.4.

후처리

  1. customThe following day, the volatiles were removed in vacuo to about 200 μL at which point the solution
  2. customwas purified by preparative TLC

출처 및 근거

ORD 기록
ord-15a35b1996df427b92aedcdbc549da79
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08153818B2

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