HCID 15554721, 화합물 → HCID 57897974, 화합물
반응식
[CH2:1]([O:3][C:4]([C:6]1[C:10]([N+:11]([O-])=O)=[C:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[O:8][N:7]=1)=[O:5])[CH3:2]>CCO.[Ni]>[CH2:1]([O:3][C:4]([C:6]1[C:10]([NH2:11])=[C:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[O:8][N:7]=1)=[O:5])[CH3:2]참가 물질
4
실험 절차
To a solution of 4-nitro-5-phenyl-isoxazole-3-carboxylic acid ethyl ester (73.0 mg, 0.278 mmol) in EtOH (2.0 mL) is added Raney Ni and the mixture is stirred under hydrogen (balloon) for overnight. The reaction mixture is then filtered through Celite and evaporated in vacuo to provide crude 4-amino-5-phenyl-isoxazole-3-carboxylic acid ethyl ester (61.7 mg, 95% yield); HPLC-MS calculated for C12H12N2O3 (M+H+) 233.1. Found: 233.1.
후처리
- filtrationThe reaction mixture is then filtered through Celite
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-23b2320ddaaf44dbaccfd5cdcee5ce10
- 출처 데이터셋
- uspto-grants-2012_04
- 특허 번호
- US08158634B2
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