Furfuryl Alcohol → Methanesulfonic acid furan-2-ylmethyl ester

HRID 1693639노트

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HRID 1693639 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][OH:7].C(N(CC)CC)C.[CH3:15][S:16](Cl)(=[O:18])=[O:17]>C(Cl)Cl>[CH3:15][S:16]([O:7][CH2:6][C:2]1[O:1][CH:5]=[CH:4][CH:3]=1)(=[O:18])=[O:17]

참가 물질

5

반응물 3

HCID 7361Furfuryl AlcoholHCID 8471TriethylamineHCID 31297Methanesulfonyl chloride

생성물 1

HCID 15031413Methanesulfonic acid furan-2-ylmethyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
0 °C

실험 절차

To the solution of furan-2-ylmethanol (500 mg, 5.1 mmol) in CH2Cl2 (10 mL) and triethylamine (1.54 g, 15.3 mmol) at 0° C. was added dropwise methanesulfonyl chloride (695 mg, 6.1 mmol). The mixture was stirred at 0° C. for 15 min and was quenched with 10 mL of water. The layers were separated and the aqueous layer was extracted with CH2Cl2 (1×10 mL). The combined organic extracts were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford the title compound.

후처리

  1. customwas quenched with 10 mL of water
  2. customThe layers were separated
  3. extractionthe aqueous layer was extracted with CH2Cl2 (1×10 mL)
  4. dry with materialThe combined organic extracts were dried over anhydrous Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e49580dd74364160a354a59d3be2d06e
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08158663B2

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