2-(Methylamino)ethanol → HCID 57537593, 화합물
반응식
[Br:1][C:2]1[C:3](Cl)=[C:4]2[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[O:17][CH3:18])=[CH:9][N:8]([CH2:19][O:20][CH2:21][CH2:22][Si:23]([CH3:26])([CH3:25])[CH3:24])[C:5]2=[N:6][CH:7]=1.[CH3:28][NH:29][CH2:30][CH2:31][OH:32]>>[Br:1][C:2]1[C:3]([N:29]([CH3:28])[CH2:30][CH2:31][OH:32])=[C:4]2[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[O:17][CH3:18])=[CH:9][N:8]([CH2:19][O:20][CH2:21][CH2:22][Si:23]([CH3:26])([CH3:25])[CH3:24])[C:5]2=[N:6][CH:7]=1참가 물질
3
반응 조건
- 온도
- 145 °C
실험 절차
5-Bromo-4-chloro-3-(2-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridine (94 mg, 0.201 mmol) was combined 2-(methylamino)ethanol (161 μL, 2.01 mmol) in a sealed tube and heated for 15 hours at 145° C. The crude product was purified by flash silica gel chromatography using a gradient of ethyl acetate in hexanes to afford 2-{[5-Bromo-3-(2-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-methyl-amino}-ethanol (67 mg, 0.132 mmol, 66% yield) as a clear oil.
후처리
- customThe crude product was purified by flash silica gel chromatography