Hydrochloric Acid → 4-[(Phenylsulfanyl)methyl]benzoic acid

HRID 1694191

반응식

HRID 1694191 반응식
Br[CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.[S-:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[Na+].Cl>C(O)C>[C:13]1([S:12][CH2:2][C:3]2[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 225994-(Bromomethyl)benzoic acidHCID 4110039Sodium benzenethiolate

생성물 1

HCID 8758244-[(Phenylsulfanyl)methyl]benzoic acid수율 88%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 4-(bromomethyl)benzoic acid (10 g, 46.5 mmol), sodium thiophenoxide (6.15 g, 46.5 mmol), and ethanol (100 mL) was stirred for 1.5 hours under reflux. This mixture was cooled to room temperature and acidified with 1 N hydrochloric acid. The precipitate thus produced was collected, dissolved in ethyl acetate, and washed with water. The organic layer was concentrated under a reduced pressure to obtain the title compound (10 g). The title compound was used in the following reaction without any further purification.

후처리

  1. temperatureunder reflux
  2. customThe precipitate thus produced
  3. customwas collected
  4. dissolutiondissolved in ethyl acetate
  5. washwashed with water
  6. concentrationThe organic layer was concentrated under a reduced pressure

출처 및 근거

ORD 기록
ord-02557a85514a465fa7c99ded696ca056
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08158657B2

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