(4-Phenylsulfanylmethyl-phenyl)-methanol → 4-[(Phenylsulfanyl)methyl]benzaldehyde

HRID 1694193노트

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HRID 1694193 반응식
[C:1]1([S:7][CH2:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][OH:16])=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[O-2].[O-2].[Mn+4].C(Cl)(Cl)Cl>[C:1]1([S:7][CH2:8][C:9]2[CH:10]=[CH:11][C:12]([CH:15]=[O:16])=[CH:13][CH:14]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 1

HCID 59255239(4-Phenylsulfanylmethyl-phenyl)-methanol

생성물 1

HCID 8202414-[(Phenylsulfanyl)methyl]benzaldehyde수율 99.9%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

실험 절차

To a chloroform (10 mL) solution of (4-phenylsulfanylmethyl-phenyl)-methanol (1 g, 4.34 mmol) described in Manufacturing Example 206-1-2 was added manganese dioxide (3.77 g, 43.4 mmol), which was stirred for 15 hours at room temperature. The manganese dioxide was removed with a Celite bed, and the filtrate was concentrated under a reduced pressure to obtain the title compound (990 mg). The title compound was used in the following reaction without any further purification.

후처리

  1. customThe manganese dioxide was removed with a Celite bed
  2. concentrationthe filtrate was concentrated under a reduced pressure

출처 및 근거

ORD 기록
ord-8f6aea560b9d413ab1ebfb8f5cbd8ec0
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08158657B2

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