Isoamyl Nitrite → 2-Chloro-4-(ethylthio)-1-iodo-benzene

HRID 1694707

반응식

HRID 1694707 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[I:9])N.C(ON=O)CC(C)C.[CH2:18]([S:20]SCC)[CH3:19]>C(#N)C>[Cl:1][C:2]1[CH:3]=[C:4]([S:20][CH2:18][CH3:19])[CH:6]=[CH:7][C:8]=1[I:9]

참가 물질

5

반응물 3

HCID 8053Isoamyl NitriteHCID 8077Diethyl disulfideHCID 2829263-Chloro-4-iodoaniline

생성물 1

HCID 672801852-Chloro-4-(ethylthio)-1-iodo-benzene

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 3-chloro-4-iodo-aniline (5.6 g), isoamylnitrite (8.8 ml) and ethyldisulphide (13.4 ml) in acetonitrile (100 ml) was heated at 60° C. for 24 h. The solvent was removed under reduced pressure and the residue purified by chromatography on silica eluting with 1% ethylacetate/isohexane. Yield 4.02 g

후처리

  1. customThe solvent was removed under reduced pressure
  2. customthe residue purified by chromatography on silica eluting with 1% ethylacetate/isohexane

출처 및 근거

ORD 기록
ord-7c48071fe59d41d998676c0323da739d
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08158820B2

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