참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Pyrimidine, 2,4-dichloro-5-methyl- | HCID 74508 | — |
| 반응물 | HCID 178486264 | HCID 178486264 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-(4-Chloro-5-methylpyrimidin-2-YL)-N-methylmethanesulfonamide | HCID 72211794 | — |
반응 단계
A mixture of N-methylsulphonamide (3.35 g), 2,4-dichloro-5-methylpyrimidine (5 g) and potassium carbonate (4.3 g) in DMF (50 ml) was heated at 80° C. for 4 h. The reaction was quenched with water (200 ml) and extracted with ethylacetate. The organics were dried, evaporated under reduced pressure and the residue triturated with ether. The solid was filtered off (4-isomer) and the filtrate evaporated under reduced pressure and subjected to RPHPLC to obtain the 2-isomer, yield 0.37 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08158820B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_04 |
|---|
| ORD ID | ord-86007e06b1a2473aa58df9d9b94b2f1b |
|---|
| 출처 메모 | uspto-grants-2012_04 |
|---|
