Ethylenediamine → N-(2-aminophenyl)-6-(2-aminoethylamino)nicotinamide

HRID 1695029노트

반응식

HRID 1695029 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:17])[C:10]1[CH:15]=[CH:14][C:13](Cl)=[N:12][CH:11]=1.[CH2:18]([NH2:21])[CH2:19][NH2:20]>>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:17])[C:10]1[CH:15]=[CH:14][C:13]([NH:20][CH2:19][CH2:18][NH2:21])=[N:12][CH:11]=1

참가 물질

3

반응물 2

HCID 3301EthylenediamineHCID 22478760N-(2-aminophenyl)-6-chloronicotinamide

생성물 1

HCID 57993739N-(2-aminophenyl)-6-(2-aminoethylamino)nicotinamide수율 55%

실험 절차

N-(2-Aminophenyl)-6-chloronicotinamide (248 mg, 1 mmol) and 5 ml of ethylenediamine were heated to 80° C. for 3 hours. The excess ethylenediamine was removed under vacuum. To the residue was added 5 ml of 0.20 M NaOH. The mixture was extracted with 100 ml of ethyl acetate. The ethyl acetate was removed under vacuum to give the title compound (150 mg, 55% yield) as a brown solid. LC-MS (m/z) 272 (M+1).

후처리

  1. customThe excess ethylenediamine was removed under vacuum
  2. additionTo the residue was added 5 ml of 0.20 M NaOH
  3. extractionThe mixture was extracted with 100 ml of ethyl acetate
  4. customThe ethyl acetate was removed under vacuum

출처 및 근거

ORD 기록
ord-dab637f7d65849f6aa4da74276418162
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08158656B2

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