Dimethylformamide → n-(2-Aminophenyl)-6-(2-(2-(((5-chloro-2-oxoindolin-3-ylidene)hydrazono)-methyl)-3,5-dimethyl-1h-pyrrole-4-carboxamido)ethylamino)nicotinamide

HRID 1695064노트

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[Cl:1][C:2]1[CH:3]=[C:4]2C(=[CH:9][CH:10]=1)NC(=O)[C:5]2=[N:12][N:13]=CC1(C)CC(C)(C(O)=O)CN1.Cl.C(N=C=NCCCN(C)C)C.[OH:37][C:38]1C2N=NNC=2[CH:41]=[CH:40][CH:39]=1.C([N:49]([CH2:52][CH3:53])[CH2:50][CH3:51])C.[NH2:54][C:55]1[CH:60]=[CH:59][CH:58]=[CH:57][C:56]=1[NH:61][C:62](=[O:73])[C:63]1[CH:68]=[CH:67][C:66]([NH:69][CH2:70][CH2:71][NH2:72])=[N:65][CH:64]=1.[CH3:74][N:75]([CH:77]=[O:78])C>[Cl-].[Na+].O>[NH2:54][C:55]1[CH:60]=[CH:59][CH:58]=[CH:57][C:56]=1[NH:61][C:62](=[O:73])[C:63]1[CH:68]=[CH:67][C:66]([NH:69][CH2:70][CH2:71][NH:72][C:38]([C:39]2[C:40]([CH3:41])=[C:52]([CH:53]=[N:13][N:12]=[C:5]3[C:4]4[C:74](=[CH:9][CH:10]=[C:2]([Cl:1])[CH:3]=4)[NH:75][C:77]3=[O:78])[NH:49][C:50]=2[CH3:51])=[O:37])=[N:65][CH:64]=1

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실험 절차

2-(((5-Chloro-2-oxoindolin-3-ylidene)hydrazono)methyl)-2,4-dimethyl-1H-pyrrole-4-carboxylic acid (344 mg, 1 mmol) and 8 ml of DMF were stirred at room temperature while 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (384 mg, 2 mmol), hydroxybenzotriazole (162 mg, 1.2 mmol), triethylamine (404 mg, 4 mmol) and N-(2-aminophenyl)-6-(2-aminoethylamino)nicotinamide (284 mg, 1.05 mmol) were added. The mixture was stirred for 20 hours at room temperature. The mixture was diluted with 400 mL of brine. The solids were collected by vacuum filtration, washed with water and dried under vacuum to give the title compound (376 mg, 63%) as a red solid. LC-MS (m/z) 598 (M+1).

후처리

additionwere added
filtrationThe solids were collected by vacuum filtration
washwashed with water
customdried under vacuum

출처 및 근거

ORD 기록: ord-7d10c4f79b9440b3a7cc5e0e53940346
출처 데이터셋: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08158656B2

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