Acetonitrile → 3-(6-Methoxy-naphthalen-2-yl)-3-oxo-propionitrile

HRID 1695219노트

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HRID 1695219 반응식
CO[C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:15][CH3:16])[CH:11]=2)[CH:6]=1)=[O:4].[H-].[Na+].[C:19](#[N:21])[CH3:20]>C1(C)C=CC=CC=1>[CH3:16][O:15][C:10]1[CH:11]=[C:12]2[C:7](=[CH:8][CH:9]=1)[CH:6]=[C:5]([C:3](=[O:4])[CH2:20][C:19]#[N:21])[CH:14]=[CH:13]2

참가 물질

5

반응물 3

HCID 6342AcetonitrileHCID 24758Sodium hydrideHCID 604020Methyl 6-methoxy-2-naphthoate

생성물 1

HCID 671886013-(6-Methoxy-naphthalen-2-yl)-3-oxo-propionitrile

시약·촉매·용매 1

HCID 1140Toluene용매

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온도
90 °C

실험 절차

To a solution of 6-methoxy-naphthalene-2-carboxylic acid methyl ester (1.0 g, 4.7 mmol) in dry toluene (8 mL), NaH (0.55 mg, 9.4 mmol) were added and the mixture was heated at 90° C. To the hot solution, acetonitrile (1.2 mL) was added dropwise. The reaction was then heated for 18 hours and the product precipitated from the reaction mixture as its sodium salt.

후처리

  1. temperatureThe reaction was then heated for 18 hours
  2. customthe product precipitated from the reaction mixture as its sodium salt

출처 및 근거

ORD 기록
ord-fd27605a8f18448884a75736b5b66078
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163729B2

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