Methyl iodide → HCID 178498598, 화합물

HRID 1695378노트

반응식

HRID 1695378 반응식
[CH3:1][O:2][C:3]([C:5]1[NH:6][N:7]=[C:8]([OH:10])[CH:9]=1)=[O:4].[C:11](=O)([O-])[O-].[Cs+].[Cs+].CI>CN(C=O)C>[CH3:1][O:2][C:3]([C:5]1[N:6]([CH3:11])[N:7]=[C:8]([OH:10])[CH:9]=1)=[O:4]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 10796Cesium carbonateHCID 1784986025-Hydroxy-1H-pyrazole-3-carboxylic acid methyl ester

생성물 1

HCID 178498598HCID 178498598, 화합물수율 17.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 5-hydroxy-2H-pyrazole-3-carboxylic acid methyl ester (2.3 g, 16 mmol) in DMF (10 mL) at room temperature was added cesium carbonate (5.27 g, 16 mmol) and methyl iodide (2.3 g, 1.0 mL, 16 mmol) and the resulting mixture stirred for 2.5 h. The mixture was then filtered off to afford the title compound (434 mg, 17%) as a white solid after trituration with ethyl acetate. MS: m/e=157.2 [M+H]+.

후처리

  1. filtrationThe mixture was then filtered off

출처 및 근거

ORD 기록
ord-f0aea6468f3442e7ab397bb7f3e12d66
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163728B2

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