Potassium Carbonate → 2-(1-(2-Nitrophenyl)ethylamino)acetonitrile

HRID 1695515

반응식

HRID 1695515 반응식
[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH2:6][NH2:7])([O-:3])=[O:2].[C:12]([O-])([O-])=O.[K+].[K+].C[CH:19](Br)[C:20]#[N:21]>C(#N)C>[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH:6]([NH:7][CH2:19][C:20]#[N:21])[CH3:12])([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 1405382-BromopropionitrileHCID 423893(2-Nitrophenyl)methanamine

생성물 1

HCID 866252282-(1-(2-Nitrophenyl)ethylamino)acetonitrile

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
65 °C

실험 절차

2-Nitrobenzylamine (513 mg, 3.37 mmol) was added to an acetonitrile (40 mL) containing K2CO3 (932 mg, 6.74 mmol) and 2-bromopropanitrile (677 mg, 5.06 mmol) under a nitrogen atmosphere. The reaction mixture was heated to 65° C. for 14 hours. The product (18) was used without purification or concentration in the next step.

후처리

  1. customThe product (18) was used without purification or concentration in the next step

출처 및 근거

ORD 기록
ord-8046259b90de42408c5cb640d8abaafc
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163738B2

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