Benzenesulfonyl chloride → N-[5-bromo-2-(ethyloxy)-3-pyridinyl]benzenesulfonamide

HRID 1695754노트

반응식

HRID 1695754 반응식
[Br:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]([O:8][CH2:9][CH3:10])=[N:6][CH:7]=1.[C:12]1([S:18](Cl)(=[O:20])=[O:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>N1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]([NH:11][S:18]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)(=[O:20])=[O:19])[C:5]([O:8][CH2:9][CH3:10])=[N:6][CH:7]=1

참가 물질

4

반응물 2

HCID 7369Benzenesulfonyl chlorideHCID 532116995-Bromo-2-ethoxypyridin-3-amine

생성물 1

HCID 59860135N-[5-bromo-2-(ethyloxy)-3-pyridinyl]benzenesulfonamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution of 5-bromo-2-(ethyloxy)-3-pyridinamine (1.45 g) in anhydrous pyridine (15 ml) was treated with benzenesulfonyl chloride (1.03 ml) then stirred at RT for 20 hr. The reaction was evaporated to dryness and the residue was purified by column chromatography on silica, eluting with 30% hexanes in DCM, to give the title compound (1.86 g).

후처리

  1. customThe reaction was evaporated to dryness
  2. customthe residue was purified by column chromatography on silica
  3. washeluting with 30% hexanes in DCM

출처 및 근거

ORD 기록
ord-087614375e224ad2a79c1264e1426db0
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163743B2

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