Sodium borohydride → Sulfonylpyran-4-ol
반응식
[S:1](=[C:4]1[CH2:9][C:8](=[O:10])[CH:7]=[CH:6][O:5]1)(=[O:3])=[O:2].[BH4-].[Na+]>CO>[S:1](=[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[CH:6][O:5]1)(=[O:3])=[O:2]참가 물질
4
실험 절차
A stirred solution of sulfonylpyran-4-one (1.2 g, 8.1 mmol) in MeOH (20 mL) was cooled to 0° C. under Argon and treated with NaBH4 (331 mg, 9.0 mmol). The reaction was stirred over 16 h and allowed to warm to ambient temperature. The solvent was removed under reduced pressure and the crude oil was chromatographed on a silica gel column packed in 50:50 EtOAc:hexanes and eluted with same. The appropriate fractions were combined and the solvent was removed under reduced pressure to give the sulfonylpyran-4-ol.
후처리
- customThe solvent was removed under reduced pressure
- customthe crude oil was chromatographed on a silica gel column
- washhexanes and eluted with same
- customthe solvent was removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-a131d665a87f4613af62e1177a8607d3
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05726172
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