Water → 4-Chloro-1H-pyrrolo[2,3-B]pyridine-3-carbonitrile

HRID 1696195노트

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HRID 1696195 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[N:8](S(C3C=CC=CC=3)(=O)=O)[CH:9]=[C:10]([C:11]#[N:12])[C:3]=12.[OH-].[Na+].O>O1CCCC1>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[NH:8][CH:9]=[C:10]([C:11]#[N:12])[C:3]=12

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 497590871H-Pyrrolo[2,3-B]pyridine-3-carbonitrile, 4-chloro-1-(phenylsulfonyl)-

생성물 1

HCID 457903004-Chloro-1H-pyrrolo[2,3-B]pyridine-3-carbonitrile

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

4-Chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile was treated with 2M NaOH solution (4 ml) in tetrahydrofuran (8 ml) at ambient temperature for 1 hour. The reaction mixture was cooled and was added water. The aqueous layer was extracted with EtOAc. And the organic layer was washed with brine, dried over MgSO4 and concentrated. Resultings were purified by silica gel column chromatography to give 4-chloro-1H-pyrrolo[2,3-b]-pyridine-3-carbonitrile as colorless powder.

후처리

  1. temperatureThe reaction mixture was cooled
  2. extractionThe aqueous layer was extracted with EtOAc
  3. washAnd the organic layer was washed with brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated
  6. customResultings were purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-0cdd8dbf809e4beeb71196efdec39bcd
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163767B2

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