Lithium hydroxide, monohydrate → 4-(2-(4-propyl-1H-1,2,3-triazol-1-yl)acetyl)morpholine-2-carboxylic acid

HRID 1696331

반응식

HRID 1696331 반응식
[CH2:1]([C:4]1[N:5]=[N:6][N:7]([CH2:9][C:10]([N:12]2[CH2:17][CH2:16][O:15][CH:14]([C:18]([O:20]CC3C=CC=CC=3)=[O:19])[CH2:13]2)=[O:11])[CH:8]=1)[CH2:2][CH3:3].O.[OH-].[Li+]>CO.O>[CH2:1]([C:4]1[N:5]=[N:6][N:7]([CH2:9][C:10]([N:12]2[CH2:17][CH2:16][O:15][CH:14]([C:18]([OH:20])=[O:19])[CH2:13]2)=[O:11])[CH:8]=1)[CH2:2][CH3:3]

참가 물질

5

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 66845266Benzyl 4-(2-(4-propyl-1H-1,2,3-triazol-1-yl)acetyl)morpholine-2-carboxylate

생성물 1

HCID 668453864-(2-(4-propyl-1H-1,2,3-triazol-1-yl)acetyl)morpholine-2-carboxylic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

In a 25-mL RBF, benzyl 4-(2-(4-propyl-1H-1,2,3-triazol-1-yl)acetyl)morpholine-2-carboxylate (0.105 g, 0.282 mmol) was taken up in MeOH (1.0 mL). Lithium hydroxide hydrate (0.0130 g, 0.310 mmol) was added as a solution in water (1.0 mL). The mixture was stirred at ambient temperature for 14 h, then concentrated, and used crude in the subsequent step. MS m/z 283 (M+1).

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-515ab79e4e3c4cd68a55a80d3c9bdb2d
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163766B2

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