Phosphorus oxybromide → HCID 57468624, 화합물

HRID 1696743노트

반응식

[F:1][C:2]([F:21])([F:20])[C:3]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[NH:6][C:5](=O)[CH:4]=1.P(Br)(Br)([Br:24])=O>>[Br:24][C:5]1[CH:4]=[C:3]([C:2]([F:21])([F:20])[F:1])[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:6]=1

참가 물질

반응물 2

HCID 24613Phosphorus oxybromide

HCID 574686224-trifluoromethyl-6-(4-trifluoromethylphenyl)-1H-pyridin-2-one

생성물 1

HCID 57468624HCID 57468624, 화합물

실험 절차

The title compound was prepared from 4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one (example A.17 step 2) (15 g, 49 mmol) and phosphoryl bromide (42 g, 146 mmol) according to the general procedure Ia to d preparation of bromides. Obtained as a brown solid (18 g, quant.). MS (EI) 368.9 [(M)+] and 370.8 [(M+2)+]; mp 35-37° C.

후처리

customObtained as a brown solid (18 g, quant.)

출처 및 근거

ORD 기록: ord-fa9b69a9301b43408ebc329e1b54a957
출처 데이터셋: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08163778B2

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