Hydrochloric Acid → (3S)-1-(pyridin-2-yl)pyrrolidin-3-amine dihydrochloride
반응식
C(OC(=O)[NH:7][C@H:8]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[CH2:9]1)(C)(C)C.[ClH:20]>O1CCOCC1.CO>[ClH:20].[ClH:20].[N:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[N:10]1[CH2:11][CH2:12][C@H:8]([NH2:7])[CH2:9]1참가 물질
5
실험 절차
To a solution of ((S)-1-pyridin-2-yl-pyrrolidin-3-yl)-carbamic acid tert-butyl ester (0.221 g, 0.84 mmol) in dioxane (4 ml) and methanol (1 ml) is added 4M HCl (in dioxane) (0.525 ml, 2.1 mmol) and the reaction mixture is stirred at room temperature overnight. The resulting suspension is filtered and washed with dioxane (3×1 ml) to yield the titled compound.
후처리
- filtrationThe resulting suspension is filtered
- washwashed with dioxane (3×1 ml)
출처 및 근거
- ORD 기록
- ord-d91c1a81bd5342dfb12cfb43bee656b5
- 출처 데이터셋
- uspto-grants-2012_04
- 특허 번호
- US08163754B2
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