Acetic Anhydride → 3-(6-Bromo-naphthalen-2-yl)-5-methyl-[1,2,4]oxadiazole
반응식
C(O[C:5](=[O:7])[CH3:6])(=O)C.[Br:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH:15]=[C:14]([C:19]([NH:21]O)=[NH:20])[CH:13]=[CH:12]2>CC1C=C(C)C=C(C)N=1>[Br:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH:15]=[C:14]([C:19]1[N:20]=[C:5]([CH3:6])[O:7][N:21]=1)[CH:13]=[CH:12]2참가 물질
4
실험 절차
6.11 ml acetic anhydride are added to 4.40 g 6-bromo-N-hydroxy-naphthalene-2-carboxamidine in 30 ml 2,4,6-trimethylpyridine. The reaction mixture is stirred for one hour at ambient temperature and then heated to 130° C. for four hours. After the reaction has ended the mixture is evaporated down in vacuo and the flask residue is stirred with ethyl acetate and petroleum ether, suction filtered and dried.
후처리
- temperatureheated to 130° C. for four hours
- customis evaporated down in vacuo
- stirringthe flask residue is stirred with ethyl acetate and petroleum ether, suction
- filtrationfiltered
- customdried
출처 및 근거
- ORD 기록
- ord-5ce417c6628c48d1804740330ea7b28a
- 출처 데이터셋
- uspto-grants-2012_04
- 특허 번호
- US08163911B2
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