Triethylamine → HCID 178513225, 화합물

HRID 1697268노트

반응식

HRID 1697268 반응식
Cl.[NH2:2][OH:3].C(N(CC)CC)C.[Br:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[CH:18]=[C:17]([C:22]#[N:23])[CH:16]=[CH:15]2>C(O)C>[Br:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[CH:18]=[C:17]([C:22]([NH:2][OH:3])=[NH:23])[CH:16]=[CH:15]2

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 443297Hydroxyamine hydrochlorideHCID 146621156-Bromonaphthalene-2-carbonitrile

생성물 1

HCID 178513225HCID 178513225, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2.48 g hydroxylamine-hydrochloride and 5.68 ml triethylamine are added to 4.10 g of 6-bromo-2-cyano-naphthalene in 100 ml of ethanol and the reaction mixture is refluxed for four hours. After cooling to ambient temperature the solvent is distilled off in vacuo using the rotary evaporator and the flask residue is divided between water and ethyl acetate. The aqueous phase is extracted with ethyl acetate and the combined organic phases are dried on magnesium sulphate and evaporated down.

후처리

  1. temperaturethe reaction mixture is refluxed for four hours
  2. distillationis distilled off in vacuo
  3. customthe rotary evaporator
  4. extractionThe aqueous phase is extracted with ethyl acetate
  5. customthe combined organic phases are dried on magnesium sulphate
  6. customevaporated down

출처 및 근거

ORD 기록
ord-de8976d12e9940d2bc603ab462d1e8e3
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163911B2

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