Hydrochloric Acid → 4-[(R)-aminophenylmethyl]-1-piperidinecarboxylic acid phenylmethyl ester

HRID 1697283노트

반응식

HRID 1697283 반응식
CC([S@]([NH:7][C@@H:8]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:16])[CH2:11][CH2:10]1)=O)(C)C.CO.Cl>O1CCOCC1>[NH2:7][C@@H:8]([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[CH:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[O:16])[CH2:11][CH2:10]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 866632334-[(R)-[[(R)-(1,1-Dimethylethyl)sulfinyl]amino]phenylmethyl]-1-piperidinecarboxylic acid, phenylmethyl ester

생성물 1

HCID 666897524-[(R)-aminophenylmethyl]-1-piperidinecarboxylic acid phenylmethyl ester수율 105.2%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of 4-[(R)-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]phenylmethyl]-1-piperidinecarboxylic acid, phenylmethyl ester (0.59 g), methanol (5 mL) and hydrogen chloride in 1,4-dioxane (4M, 5 mL) was stirred at room temperature for 10 minutes then concentrated in vacuo. The residue was diluted in dichloromethane (2 mL) and triturated with diethyl ether to afford the subtitle compound as a solid (470 mg).

후처리

  1. concentrationthen concentrated in vacuo
  2. additionThe residue was diluted in dichloromethane (2 mL)
  3. customtriturated with diethyl ether

출처 및 근거

ORD 기록
ord-d7bb9290769f4a98bb573e792340ad89
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163905B2

반응 노트

불러오는 중…