Lithium Hydroxide → HCID 178525800, 화합물

HRID 1697682노트

반응식

C[O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:21])[F:20])(=[O:12])=[O:11])[CH2:7][N:6]1[C:23]1[NH:24][N:25]=[C:26]([CH:28]2[CH2:30][CH2:29]2)[CH:27]=1)=[O:4].[OH-].[Li+]>>[CH:28]1([C:26]2[CH:27]=[C:23]([N:6]3[CH2:7][C@H:8]([S:10]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=4[C:19]([F:22])([F:20])[F:21])(=[O:12])=[O:11])[CH2:9][C@H:5]3[C:3]([OH:4])=[O:2])[NH:24][N:25]=2)[CH2:29][CH2:30]1

참가 물질

반응물 2

HCID 3939Lithium Hydroxide

HCID 178501348HCID 178501348, 화합물

생성물 1

HCID 178525800HCID 178525800, 화합물

실험 절차

In analogy to the procedure described in example 253e, (2S,4R)-1-(5-cyclopropyl-2H-pyrazol-3-yl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester was saponified in the presence of lithium hydroxide to give the title compound as brown solid which was used in the next step without further purification.

출처 및 근거

ORD 기록: ord-5f5dc102c37b4ac4bbfa2905a09d9532
출처 데이터셋: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08163793B2

반응 노트

불러오는 중…