Lawesson's reagent → HCID 66770398, 화합물

HRID 1697691

반응식

HRID 1697691 반응식
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:21])[F:20])(=[O:12])=[O:11])[CH2:7][N:6]1[C:23](=O)[CH2:24][C:25](=O)[CH3:26])=[O:4].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=S)=CC=1.[CH2:51]([O:58][C:59]([N:61]1[CH2:66][CH2:65][CH:64]([NH:67][NH2:68])[CH2:63][CH2:62]1)=[O:60])[C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1>>[CH2:51]([O:58][C:59]([N:61]1[CH2:62][CH2:63][CH:64]([N:67]2[C:23]([N:6]3[CH2:7][C@H:8]([S:10]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=4[C:19]([F:22])([F:21])[F:20])(=[O:12])=[O:11])[CH2:9][C@H:5]3[C:3]([O:2][CH3:1])=[O:4])=[CH:24][C:25]([CH3:26])=[N:68]2)[CH2:65][CH2:66]1)=[O:60])[C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1

참가 물질

4

반응물 3

HCID 87949Lawesson's reagentHCID 21098319Benzyl 4-hydrazinylpiperidine-1-carboxylateHCID 86646859HCID 86646859, 화합물

생성물 1

HCID 66770398HCID 66770398, 화합물

실험 절차

In analogy to the procedure described in example 308d, (2S,4R)-1-(3-oxo-butyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester (example 192f) was reacted with Lawesson's reagent (CAS Reg. No. 19172-47-5) and 4-hydrazino-piperidine-1-carboxylic acid benzyl ester (CAS Reg. No. 280111-51-5) to give the title compound as yellow oil.

출처 및 근거

ORD 기록
ord-9b56101290c04bc299c08046e3f217fe
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163793B2

연결된 노트

불러오는 중…