반응식
C([O:3][C:4]([CH:6]1[CH2:10][CH:9]([S:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)(=[O:13])=[O:12])[CH:8]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([CH3:29])([CH3:28])[CH3:27])=[CH:22][CH:21]=2)[NH:7]1)=[O:5])C.[OH-].[Li+]>>[C:26]([C:23]1[CH:22]=[CH:21][C:20]([CH:8]2[NH:7][CH:6]([C:4]([OH:5])=[O:3])[CH2:10][CH:9]2[S:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)(=[O:13])=[O:12])=[CH:25][CH:24]=1)([CH3:29])([CH3:27])[CH3:28]참가 물질
3
실험 절차
In analogy to the procedure described in example 253e, 5-(4-tert-butylphenyl)-4-(phenylsulfonyl)pyrrolidine-2-carboxylic acid ethyl ester was saponified in the presence of lithium hydroxide to give the title compound as colorless solid which was used in the next step without further purification. MS (ESI): m/z=388.2 [M+H]
출처 및 근거
- ORD 기록
- ord-14433362cc5e446a88da13f7ddbbfb03
- 출처 데이터셋
- uspto-grants-2012_04
- 특허 번호
- US08163793B2
연결된 노트
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