Morpholine → HCID 59239393, 화합물

HRID 1697894노트

반응식

HRID 1697894 반응식
[CH2:1]([N:8]1[CH2:16][C:15]2[C:14](Cl)=[N:13][C:12]([Cl:18])=[N:11][C:10]=2[C:9]1=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)C(C)C)(C)C.[NH:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>C(O)(C)C>[CH2:1]([N:8]1[CH2:16][C:15]2[C:14]([N:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)=[N:13][C:12]([Cl:18])=[N:11][C:10]=2[C:9]1=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 8083MorpholineHCID 81531DiisopropylethylamineHCID 592394402,4-Dichloro-5,6-dihydro-6-(phenylmethyl)-7H-pyrrolo[3,4-d]pyrimidin-7-one

생성물 1

HCID 59239393HCID 59239393, 화합물

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

6-benzyl-2,4-dichloro-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one (cw) (0.125 g, 0.000425 mol), isopropyl alcohol (2.90 mL), N,N-diisopropylethylamine (0.150 mL, 0.861 mmol) and morpholine (0.0556 mL, 0.638 mmol) were mixed and the mixture was stirred for 30 minutes. The reaction mixture was concentrated. The resulting residue was chromatographed through silica gel (40 g, 0-5% MeOH in dichloromethane) to give the compound cx (0.126 g, 86%).

후처리

  1. concentrationThe reaction mixture was concentrated
  2. customThe resulting residue was chromatographed through silica gel (40 g, 0-5% MeOH in dichloromethane)
  3. customto give the compound cx (0.126 g, 86%)

출처 및 근거

ORD 기록
ord-43f09ab8aa2e4c33ba2a514d5fc1a268
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163763B2

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