Hydrochloric Acid → (3-Bromo-1,2-oxazol-5-yl)methanamine hydrochloride

HRID 1698220노트

반응식

HRID 1698220 반응식
[Br:1][C:2]1[CH:6]=[C:5]([CH2:7][NH:8]S(C(C)(C)C)=O)[O:4][N:3]=1.[ClH:15].O1CCOCC1>CO>[ClH:15].[Br:1][C:2]1[CH:6]=[C:5]([CH2:7][NH2:8])[O:4][N:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66727644HCID 66727644, 화합물

생성물 1

HCID 21292272(3-Bromo-1,2-oxazol-5-yl)methanamine hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 2-methyl-propane-2-sulfinic acid (3-bromo-isoxazol-5-ylmethyl)-amide (128 mg, 0.455 mmol) in MeOH (5 mL) was added a 4 M solution of HCl in dioxane (0.350 mL, 1.40 mmol) dropwise. After 2 hours and 10 minutes, the reaction mixture was concentrated in vacuo to afford the title compound which was used without further purification.

후처리

  1. concentration10 minutes, the reaction mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-46796126241e4eaba574ee372fa87aef
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163918B2

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