반응식
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]1[N:11]=[C:12]([N:16]([C:20]2[CH:25]=[C:24]([C:26]([OH:28])=[O:27])[CH:23]=[CH:22][C:21]=2[O:29][CH3:30])[CH2:17][CH2:18][CH3:19])[S:13][C:14]=1[CH3:15].C([O-])([O-])=O.[Cs+].[Cs+].[CH2:37](I)[CH3:38]>CN(C)C=O.C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]1[N:11]=[C:12]([N:16]([C:20]2[CH:25]=[C:24]([C:26]([O:28][CH2:37][CH3:38])=[O:27])[CH:23]=[CH:22][C:21]=2[O:29][CH3:30])[CH2:17][CH2:18][CH3:19])[S:13][C:14]=1[CH3:15]참가 물질
6
반응물 3
생성물 1
시약·촉매·용매 2
실험 절차
1 g of 4-(2-chloro-4-methoxyphenyl)-5-methyl-2-[N-(5-carboxy-2methoxyphenyl)-N-propylamino]thiazole (EXAMPLE 3) is dissolved at room temperature and under argon in 3 ml of dimethylformamide and then 0.66 g of Cs2CO3 and 0.5 ml of ethyl iodide are added. The reaction mixture is stirred for one hour and then diluted with ethyl acetate. It is washed with water, dried over sodium sulphate and evaporated to dryness. The residue is purified by chromatography on a silica gel column eluted with a cyclohexane/ethyl acetate 5/1 (v/v) mixture. The expected product is obtained in the form of a colourless oil.
후처리
- washIt is washed with water
- dry with materialdried over sodium sulphate
- customevaporated to dryness
- customThe residue is purified by chromatography on a silica gel column
- washeluted with a cyclohexane/ethyl acetate 5/1 (v/v) mixture
출처 및 근거
- ORD 기록
- ord-37ee00064d1e4c8ab4b2bc1d16616d30
- 출처 데이터셋
- uspto-grants-2002_02
- 특허 번호
- US06344470B1
연결된 노트
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