1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → 3-[4-(3-Bromo-phenylamino)-quinazolin-7-ylcarbamoyl]acrylic acid ethyl ester

HRID 1698938노트

반응식

HRID 1698938 반응식
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([Br:19])[CH:14]=3)=[N:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[C:20]([O:27][CH2:28][CH3:29])(=[O:26])/[CH:21]=[CH:22]/[C:23]([O-])=[O:24].Cl.CN(C)CCCN=C=NCC>CN(C)C=O>[CH2:28]([O:27][C:20](=[O:26])[CH:21]=[CH:22][C:23](=[O:24])[NH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([Br:19])[CH:14]=3)=[N:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1)[CH3:29]

참가 물질

5

반응물 3

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 53280457-Amino-4-[(3-bromophenyl)amino]quinazoline2회HCID 58782252-Butenedioic acid, monoethyl ester

생성물 1

HCID 537015123-[4-(3-Bromo-phenylamino)-quinazolin-7-ylcarbamoyl]acrylic acid ethyl ester수율 23.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
5 °C

실험 절차

To an ice cold solution of 0.158 g of 7-amino-4(3-bromoanilino)-quinazoline and 0.216 g of monoethyl fumarate in 3 mL of dry dimethylformamide was added 0.288 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide HCl (EDAC). 7-Amino-4-(3-bromoanilino)quinazoline can be made by methods well-known to those skilled in the art. See, for example, J Med Chem, 1995:3482, which is hereby incorporated by reference. After stirring at 5° C. for 5 minutes, the ice bath was removed, and the reaction was permitted to warm to room temperature where it stirred for 15 hours. The reaction was poured into cold water, and the suspension was made basic with the addition of a saturated sodium bicarbonate solution. The resulting solid was collected by filtration, washed with water, and then recrystallized from 50 mL of ethanol to afford 0.052 g of the desired product, mp >260° C.

후처리

  1. customthe ice bath was removed
  2. temperatureto warm to room temperature where it
  3. stirringstirred for 15 hours
  4. additionThe reaction was poured into cold water
  5. additionthe suspension was made basic with the addition of a saturated sodium bicarbonate solution
  6. filtrationThe resulting solid was collected by filtration
  7. washwashed with water
  8. customrecrystallized from 50 mL of ethanol

출처 및 근거

ORD 기록
ord-fe4d16ab9b75447683ce20a5502c1efc
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06344459B1

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