Hydrogen Bromide → 1-(Bromomethyl)-4-(2-methylpropyl)benzene

HRID 1699007노트

반응식

HRID 1699007 반응식
[BrH:1].[CH2:2]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12]O)=[CH:8][CH:7]=1)[CH:3]([CH3:5])[CH3:4]>CCOCC>[CH2:2]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][Br:1])=[CH:8][CH:7]=1)[CH:3]([CH3:5])[CH3:4]

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 14620446[4-(2-Methylpropyl)phenyl]methanol

생성물 1

HCID 146204471-(Bromomethyl)-4-(2-methylpropyl)benzene

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

HBr gas was bubbled through a solution of (4-isobutyl-phenyl)-methanol (5 g, 28 mmol) in Et2O (50 mL) for 10-15 minutes. The reaction was stirred for 1 h and was poured onto ice (100 g). Et2O was added and the organic solution was washed with brine (2×). The organic solution was dried (MgSO4), filtered, and concentrated to provide the title compound (6 g). 1H NMR (400 MHz, CDCl3) δ7.28 (d, 2H), 7.10 (d, 2H), 4.49 (s, 2H), 2.45 (d, 2H), 1.84 (m, 1H), 0.89 (d, 6H).

후처리

  1. additionwas poured onto ice (100 g)
  2. washthe organic solution was washed with brine (2×)
  3. dry with materialThe organic solution was dried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-64d1464bc70f4693a96514d804ef5629
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06344485B1

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