Acetic Anhydride → 4-Acetamido-3-methoxybenzyl alcohol
반응식
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][C:3]=1[O:10][CH3:11].[C:12](OC(=O)C)(=[O:14])[CH3:13]>CO>[C:12]([NH:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][C:3]=1[O:10][CH3:11])(=[O:14])[CH3:13]참가 물질
4
실험 절차
To a solution of 4-amino-3-methoxybenzyl alcohol (900 mg) in methanol was added acetic anhydride (1.8 g) under ice cooling, and the mixture was stirred for 1 hour at the same temperature. After evaporation, the residue was dissolved in ethyl acetate, and the solution was washed with sodium bicarbonate solution, water and brine, dried over magnesium sulfate and concentrated in vacuo to give 4-acetamido-3-methoxybenzyl alcohol (840 mg) as solid.
후처리
- customAfter evaporation
- dissolutionthe residue was dissolved in ethyl acetate
- washthe solution was washed with sodium bicarbonate solution, water and brine
- dry with materialdried over magnesium sulfate
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-ba8d3f61add94b9da9997702f5a744be
- 출처 데이터셋
- uspto-grants-2002_02
- 특허 번호
- US06344462B1
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