Water → Dihydroartemisinin ethyl ether

HRID 1699478

반응식

HRID 1699478 반응식
[CH3:1][C@H:2]1[C@@H:11]2[CH2:12][CH2:13][C:14]3([CH3:18])[O:16][O:17][C@:10]42[C@H:5]([C@@H:6]([CH3:20])[C@@H:7]([OH:19])[O:8][C@@H:9]4[O:15]3)[CH2:4][CH2:3]1.[CH2:21](OC(OCC)OCC)[CH3:22].O>C(O)C>[CH3:21][CH2:22][O:19][C@H:7]1[O:8][C@@H:9]2[O:15][C:14]3([CH3:18])[O:16][O:17][C@@:10]42[C@@H:5]([CH2:4][CH2:3][C@@H:2]([CH3:1])[C@@H:11]4[CH2:12][CH2:13]3)[C@H:6]1[CH3:20]

참가 물질

5

반응물 3

HCID 962WaterHCID 31214Ethyl orthoformateHCID 456410Npc182939

생성물 1

HCID 72416Dihydroartemisinin ethyl ether

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Dihydroartemisinin (50 mg) was dissolved in 3 ml dry ethanol with stirring the solution for 10 min. at room temperature and add cation exchange resin (Dowex-50, 50 mg) and triethylorthoformate (4 ml) in the solution. The reaction mixture is stirred for 10 hrs at room temperature (30° C.). Water was added in the reaction mixture and filters the cation exchange resin. The reaction product was extracted by dichloromethane. The organic layer was separated, dried over anhydrous sodium sulphate and evaporated under vacuum to yield pure arteether (50 mg).

후처리

  1. stirringThe reaction mixture is stirred for 10 hrs at room temperature (30° C.)
  2. extractionThe reaction product was extracted by dichloromethane
  3. customThe organic layer was separated
  4. dry with materialdried over anhydrous sodium sulphate
  5. customevaporated under vacuum

출처 및 근거

ORD 기록
ord-27d23df026d04dff94bd070d683976bf
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06346631B1

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