Pyridine → Phenol, 3-chloro-4-methyl-, acetate

HRID 1699948

반응식

HRID 1699948 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[CH3:8].[C:10](OC(=O)C)(=[O:12])[CH3:11].N1C=CC=CC=1>CCOCC>[C:10]([O:9][C:4]1[CH:5]=[CH:6][C:7]([CH3:8])=[C:2]([Cl:1])[CH:3]=1)(=[O:12])[CH3:11]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 148533-Chloro-4-methylphenol

생성물 1

HCID 538898Phenol, 3-chloro-4-methyl-, acetate수율 99.6%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a solution of 3-chloro-4-methylphenol (500 mg) in ether (5.0 ml) were added acetic anhydride (430 mg) and pyridine (416 mg), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was washed with 1N hydrochloric acid (once) and saturated brine (twice), dried over magnesium sulfate and concentrated to dryness under reduced pressure to give the objective compound (645 mg) as a pale-yellow oil.

후처리

  1. washThe reaction mixture was washed with 1N hydrochloric acid (once) and saturated brine (twice),
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-c48fbec94d474d7dbe779e1c160e34bf
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06348474B1

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