Hydrochloric Acid → HCID 54335685, 화합물

반응식

[O:1]=[C:2]([C:7]([CH3:10])([CH3:9])[CH3:8])[C:3]([NH:5][CH3:6])=[O:4].Cl>CO.C(Cl)Cl>[OH:1][C@@H:2]([C:7]([CH3:10])([CH3:9])[CH3:8])[C:3]([NH:5][CH3:6])=[O:4]

참가 물질

실험 절차

The experiment was carried out in an analogous manner to Example 1. The asymmetric hydrogenation of 55.0 g (0.384 mol) of 2-keto-3,3,N-trimethyl-butyramide in 270 ml of methanol and 30 ml of methylene chloride in the presence of a catalyst prepared from 296 mg (0.384 mmol) of [Ru(OAc)2((S)-BIPHEMP)] and 31 ml of a 0.025 molar methanolic hydrochloric acid solution gave, after crystallization, 34.4 g (62%) of (S)-2-hydroxy-3,3,N-trimethyl-butyramide, m.p.=60-62° C., [α]=−59.9° (c=1, CHCl3), ee=99.2%.

후처리

customgave
customafter crystallization, 34.4 g (62%) of (S)-2-hydroxy-3,3,N-trimethyl-butyramide, m.p.=60-62° C., [α]=−59.9° (c=1, CHCl3), ee=99.2%

출처 및 근거

ORD 기록: ord-15a7b538dd284072a1e8b046786d3c00
출처 데이터셋: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06348612B1

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참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 13355140HCID 13355140, 화합물

생성물 1

HCID 54335685HCID 54335685, 화합물

시약·촉매·용매 2

HCID 887Methanol용매

HCID 6344Dichloromethane용매

실험 절차

후처리

customgave
customafter crystallization, 34.4 g (62%) of (S)-2-hydroxy-3,3,N-trimethyl-butyramide, m.p.=60-62° C., [α]=−59.9° (c=1, CHCl3), ee=99.2%

출처 및 근거

ORD 기록: ord-15a7b538dd284072a1e8b046786d3c00
출처 데이터셋: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06348612B1

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불러오는 중…