Diisopropylethylamine → Ethyl 1-({[2-(5-chloro-1H-indol-3-yl)ethyl]amino}carbonyl)cyclobutanecarboxylate

HRID 1700362노트

반응식

HRID 1700362 반응식
Cl.[Cl:2][C:3]1[CH:14]=[C:13]2[C:6]([NH:7][CH:8]=[C:9]2[CH2:10][CH2:11][NH2:12])=[CH:5][CH:4]=1.[C:15]1([C:24]([O-])=[O:25])([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:18][CH2:17][CH2:16]1.C(N(C(C)C)CC)(C)C.F[B-](F)(F)F.N1(OC(N(C)C)=[N+](C)C)C2C=CC=CC=2N=N1>ClCCl>[Cl:2][C:3]1[CH:14]=[C:13]2[C:6](=[CH:5][CH:4]=1)[NH:7][CH:8]=[C:9]2[CH2:10][CH2:11][NH:12][C:24]([C:15]1([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:18][CH2:17][CH2:16]1)=[O:25]

참가 물질

6

반응물 4

HCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 28274945-Chloro-1H-indole-3-ethylamine monohydrochlorideHCID 18317994Monoethyl 1,1-cyclobutanedicarboxylate

생성물 1

HCID 11163887Ethyl 1-({[2-(5-chloro-1H-indol-3-yl)ethyl]amino}carbonyl)cyclobutanecarboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

23.1 g of 5-chlorotryptamine hydrochloride, 17.3 g of monoethyl cyclobutanedicarboxylate, 36 ml of diisopropylethylamine and 33.7 g of O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate are stirred for 20 hours at ambient temperature in 200 ml of dichloromethane. After washing with water, drying over sodium sulphate and filtering off the organic phase over Celite, evaporation under reduced pressure enables the expected product to be isolated.

후처리

  1. washAfter washing with water
  2. dry with materialdrying over sodium sulphate
  3. filtrationfiltering off the organic phase
  4. customover Celite, evaporation under reduced pressure
  5. customto be isolated

출처 및 근거

ORD 기록
ord-ab50d7e3732f4d9f96748499779790a2
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06350757B1

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