Hydroxyamine hydrochloride → HCID 88186782, 화합물

HRID 1700381노트

반응식

HRID 1700381 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH:9]([C:15]3([CH:19]=[O:20])[CH2:18][CH2:17][CH2:16]3)[NH:8][CH2:7][CH2:6][C:5]2=1.Cl.[NH2:22][OH:23]>C(O)C.C(N(CC)CC)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH:9]([C:15]3([C:19]([NH:22][OH:23])=[O:20])[CH2:18][CH2:17][CH2:16]3)[NH:8][CH2:7][CH2:6][C:5]2=1

참가 물질

5

반응물 2

HCID 443297Hydroxyamine hydrochlorideHCID 183179861-(6-Chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)cyclobutanecarboxaldehyde

생성물 1

HCID 88186782HCID 88186782, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8471Triethylamine용매

실험 절차

A solution of 1.2 g of the compound obtained in Step A in 120 ml of ethanol, 0.54 ml of triethylamine and 0.27 g of hydroxylarnine hydrochloride is stirred for 6 hours and then concentrated under reduced pressure. Chromatography on silica gel (dichloromethane/ethyl acetate: 98/2) enables the expected product to be isolated.

후처리

  1. concentrationconcentrated under reduced pressure
  2. customto be isolated

출처 및 근거

ORD 기록
ord-33124569a369431e92c960347e745636
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06350757B1

반응 노트

불러오는 중…