Hydrazine hydrate (1:1) → 3-Methyl-6-(2-chlorophenyl)-4,5,6,7-tetrahydroindazol-4-one

HRID 1700450노트

반응식

HRID 1700450 반응식
O[C:2](=[C:4]1[C:9](=O)[CH2:8][CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[Cl:17])[CH2:6][C:5]1=[O:18])[CH3:3].O.[NH2:20][NH2:21]>C(O)C>[Cl:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[CH:7]1[CH2:8][C:9]2[NH:21][N:20]=[C:2]([CH3:3])[C:4]=2[C:5](=[O:18])[CH2:6]1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 178467253HCID 178467253, 화합물

생성물 1

HCID 1784341903-Methyl-6-(2-chlorophenyl)-4,5,6,7-tetrahydroindazol-4-one수율 85.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 2-(1-hydroxyethylidene)-5-(2-chlorophenyl)cyclohexane-1,3-dione (0.31 g) and hydrazine hydrate (0.065 g) in ethanol (10 ml) was refluxed for 30 minutes. Under reduced pressure, the solvent was evaporated, and the residue was recrystallized from ethyl acetate-hexane to give colorless crystals of 6-(2-chlorophenyl)-3-methyl-4,5,6,7-tetrahydroindazol-4-one (0.26 g).

후처리

  1. customUnder reduced pressure, the solvent was evaporated
  2. customthe residue was recrystallized from ethyl acetate-hexane

출처 및 근거

ORD 기록
ord-4714fccebfb64bd08104b79029209840
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06350749B1

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