Hydrochloric Acid → HCID 178430974, 화합물

HRID 1700537노트

반응식

HRID 1700537 반응식
[CH3:1][S:2]([N:5]1[C:13]2[CH2:12][CH:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:10][C:9](=O)[C:8]=2[C:7]([CH3:21])=[CH:6]1)(=[O:4])=[O:3].[C:22]([NH:25][NH2:26])([NH2:24])=[NH:23].[ClH:27].Cl.O>C(O)C>[ClH:27].[NH:25]([N:26]=[C:9]1[CH2:10][CH:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:12][C:13]2[N:5]([S:2]([CH3:1])(=[O:4])=[O:3])[CH:6]=[C:7]([CH3:21])[C:8]1=2)[C:22]([NH2:24])=[NH:23]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 18317470HCID 18317470, 화합물HCID 178418668HCID 178418668, 화합물

생성물 1

HCID 178430974HCID 178430974, 화합물수율 46.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 1-methanesulfonyl-3-methyl-6-phenyl-4,5,6,7-tetrahydroindol-4-one (0.41 g), aminoguanidine hydrochloride (0.16 g), concentrated hydrochloric acid (0.068 ml), water (0.068 ml) and ethanol (30 ml) was refluxed for 20 minutes. The reaction solution was allowed to stand in a refrigerator for 12 hours, and precipitated crystals were filtered, which were washed with ethanol and recrystallized from water to give 4-guanidinoimino-1-methanesulfonyl-3-methyl-6-phenyl-4,5,6,7-tetrahydroindole hydrochloride (Compound 13) (0.25 g) as colorless crystals.

후처리

  1. temperaturewas refluxed for 20 minutes
  2. customprecipitated crystals
  3. filtrationwere filtered
  4. washwhich were washed with ethanol
  5. customrecrystallized from water

출처 및 근거

ORD 기록
ord-07ed04ea9a6644dbbf0249f011d8004f
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06350749B1

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