Hydrochloric Acid → HCID 178423650, 화합물

HRID 1700569노트

반응식

HRID 1700569 반응식
[CH3:1][C:2]1[S:6][C:5]([CH:7]2[CH2:16][C:15](=O)[C:10]3[C:11](C)=[CH:12][O:13][C:9]=3[CH2:8]2)=[CH:4][CH:3]=1.[C:18]([NH:21][NH2:22])([NH2:20])=[NH:19].[ClH:23].Cl.[CH2:25](O)C>>[ClH:23].[NH:21](/[N:22]=[C:15]1\[CH:16]([CH3:25])[CH:7]([C:5]2[S:6][C:2]([CH3:1])=[CH:3][CH:4]=2)[CH2:8][C:9]2[O:13][CH:12]=[CH:11][C:10]\1=2)[C:18]([NH2:20])=[NH:19]

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 183175876-(5-Methyl-2-thienyl)-3-methyl-4,5,6,7-tetrahydrobenzofuran-4-oneHCID 178418668HCID 178418668, 화합물

생성물 1

HCID 178423650HCID 178423650, 화합물

반응 조건

온도
90 °C

실험 절차

To a mixture of 6-(5-methyl-2-thienyl)-3-methyl-4,5,6,7-tetrahydrobenzofuran-4-one (0.18 g) and aminoguanidine hydrochloride (81 mg) were added ethanol (15 ml) and 6N hydrochloric acid (0.063 ml), and the mixture was stirred at 90° C. for 2 hours and cooled. The reaction solution was concentrated under reduced pressure, and the residue was washed with ethanol, ethyl acetate and isopropylether, and dried to give (E)-4-guanidinoimino-6-(5-methyl-2-thienyl)-5-methyl-4,5,6,7-tetrahydrobenzofuran hydrochloride (Compound 49) (0.18 g).

후처리

  1. temperaturecooled
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. washthe residue was washed with ethanol, ethyl acetate and isopropylether
  4. customdried

출처 및 근거

ORD 기록
ord-b727f9491dd44d479cc28fa73c74fc5a
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06350749B1

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