Hydrochloric Acid → HCID 178479522, 화합물

HRID 1700571노트

반응식

HRID 1700571 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:20][C:19](=O)[C:11]3[C:12]([C:15]([F:18])([F:17])[F:16])=[CH:13][O:14][C:10]=3[CH2:9]2)=[CH:4][CH:3]=1.[C:22]([NH:25][NH2:26])([NH2:24])=[NH:23].[ClH:27].Cl>C(O)C>[ClH:27].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:20]/[C:19](=[N:26]\[NH:25][C:22]([NH2:24])=[NH:23])/[C:11]3[C:12]([C:15]([F:18])([F:17])[F:16])=[CH:13][O:14][C:10]=3[CH2:9]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 183176886-(4-Fluorophenyl)-3-trifluoromethyl-4,5,6,7-tetrahydrobenzofuran-4-oneHCID 178418668HCID 178418668, 화합물

생성물 1

HCID 178479522HCID 178479522, 화합물수율 61.1%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
90 °C

실험 절차

To a mixture of 6-(4-fluorophenyl)-3-trifluoromethyl-4,5,6,7-tetrahydrobenzofuran-4-one (0.25 g) and aminoguanidine hydrochloride (93 mg) were ethanol (20 ml) and 6N hydrochloric acid (0.072 ml), and the mixture was stirred at 90° C. for 4 hours and cooled. The reaction solution was concentrated under reduced pressure, and the residue was washed with ethanol, ethyl acetate and isopropylether, and dried to give (E)-6-(4-fluorophenyl)-4-guanidinoimino-3-trifluoromethyl-4,5,6,7-tetrahydrobenzofuran hydrochloride (Compound 51) (0.20 g).

후처리

  1. temperaturecooled
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. washthe residue was washed with ethanol, ethyl acetate and isopropylether
  4. customdried

출처 및 근거

ORD 기록
ord-bf33958d6d28477ab2e2478ffa8cc97b
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06350749B1

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