Hydrochloric Acid → 5-Guanidinoimino-4-methyl-7-(5-methyl-2-thienyl)-5,6,7,8-tetrahydroquinoline hydrochloride

HRID 1700591노트

반응식

HRID 1700591 반응식
[CH3:1][C:2]1[C:11]2[C:10](=O)[CH2:9][CH:8]([C:13]3[S:14][C:15]([CH3:18])=[CH:16][CH:17]=3)[CH2:7][C:6]=2[N:5]=[CH:4][CH:3]=1.[C:19]([NH:22][NH2:23])([NH2:21])=[NH:20].[ClH:24].Cl>C(O)C>[ClH:24].[NH:22]([N:23]=[C:10]1[CH2:9][CH:8]([C:13]2[S:14][C:15]([CH3:18])=[CH:16][CH:17]=2)[CH2:7][C:6]2[N:5]=[CH:4][CH:3]=[C:2]([CH3:1])[C:11]1=2)[C:19]([NH2:21])=[NH:20]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 183176484-Methyl-7-(5-methyl-2-thienyl)-5,6,7,8-tetrahydroquinolin-5-oneHCID 178418668HCID 178418668, 화합물

생성물 1

HCID 1784238315-Guanidinoimino-4-methyl-7-(5-methyl-2-thienyl)-5,6,7,8-tetrahydroquinoline hydrochloride수율 78.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 4-methyl-7-(5-methyl-2-thienyl)-5,6,7,8-tetrahydroquinolin-5-one (257 mg), aminoguanidine hydrochloride (117 mg) and concentrated hydrochloric acid (0.2 ml) in ethanol (5 ml) was refluxed for 30 minutes. The reaction solution was cooled, and precipitated crystals were filtered, washed with ethanol and dried to give 5-guanidinoimino-4-methyl-7-(5-methyl-2-thienyl)-5,6,7,8-tetrahydroquinoline hydrochloride (Compound 71) (273 mg) as pale yellow crystals.

후처리

  1. temperaturewas refluxed for 30 minutes
  2. temperatureThe reaction solution was cooled
  3. customprecipitated crystals
  4. filtrationwere filtered
  5. washwashed with ethanol
  6. customdried

출처 및 근거

ORD 기록
ord-299fc33957474ea7815f92a1af9c4c05
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06350749B1

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