Ammonium Acetate → 1-Amino-5-(2-fluoro-5-methylphenyl)cyclohexen-3-one

HRID 1700696노트

반응식

HRID 1700696 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[CH:9]1[CH2:14][C:13](=O)[CH2:12][C:11](=[O:16])[CH2:10]1.C([O-])(=O)C.[NH4+:21]>C(O)C>[NH2:21][C:13]1[CH2:14][CH:9]([C:3]2[CH:4]=[C:5]([CH3:8])[CH:6]=[CH:7][C:2]=2[F:1])[CH2:10][C:11](=[O:16])[CH:12]=1

참가 물질

4

반응물 2

HCID 517165Ammonium AcetateHCID 183174315-(2-Fluoro-5-methylphenyl)cyclohexane-1,3-dione

생성물 1

HCID 183176231-Amino-5-(2-fluoro-5-methylphenyl)cyclohexen-3-one수율 87.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 5-(2-fluoro-5-methylphenyl)cyclohexane-1,3-dione (1.5 g) and ammonium acetate (1.6 g) in ethanol (23 ml) was refluxed for 20 hours. Under reduced pressure, the solvent was evaporated, and precipitated crystals were washed with water and toluene, and dried to give 1-amino-5-(2-fluoro-5-methylphenyl)cyclohexen-3-one (1.3 g).

후처리

  1. customUnder reduced pressure, the solvent was evaporated
  2. customprecipitated crystals
  3. washwere washed with water and toluene
  4. customdried

출처 및 근거

ORD 기록
ord-15bf297343ad43148504d34913f2ae9b
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06350749B1

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