Acetone → 4-(5-Fluoro-2-methylphenyl)-3-buten-2-one

HRID 1700714노트

반응식

HRID 1700714 반응식
[OH-].[Na+].O.[F:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:13])=[C:9]([CH:12]=1)[CH:10]=O.[CH3:14][C:15]([CH3:17])=[O:16]>>[F:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:13])=[C:9]([CH:10]=[CH:14][C:15](=[O:16])[CH3:17])[CH:12]=1

참가 물질

5

반응물 4

HCID 180Acetone2회HCID 962WaterHCID 14798Sodium HydroxideHCID 27590125-Fluoro-2-methylbenzaldehyde

생성물 1

HCID 540396424-(5-Fluoro-2-methylphenyl)-3-buten-2-one

실험 절차

To a mixture of acetone (80 ml), sodium hydroxide (3.7 g) and water (100 ml) was added dropwise at room temperature a solution of 5-fluoro-2-methylbenzaldehyde (11.5 g) in acetone (30 ml), and the mixture was stirred at the same temperature for 1 hour. Under reduced pressure, acetone was evaporated, and the residue was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and concentrated under reduced pressure to give 4-(5-fluoro-2-methylphenyl)-3-buten-2-one (13.4 g).

후처리

  1. customUnder reduced pressure, acetone was evaporated
  2. extractionthe residue was extracted with ethyl acetate
  3. washThe organic layer was washed with water and saturated brine
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-bf8e065908ac478db9dae47735935d87
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06350749B1

반응 노트

불러오는 중…