Hydrochloric Acid → 6-(2-Chlorophenyl)-4-guanidinoimino-3-methyl-2-phenyl-4,5,6,7-tetrahydroindazole hydrochloride

HRID 1700737노트

반응식

HRID 1700737 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:16][C:15]2[C:11](=[C:12]([CH3:23])[N:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:14]=2)[C:10](=O)[CH2:9]1.[C:25]([NH:28][NH2:29])([NH2:27])=[NH:26].Cl.Cl.O>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:16][C:15]2[C:11](=[C:12]([CH3:23])[N:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:14]=2)[C:10](=[N:29][NH:28][C:25]([NH2:27])=[NH:26])[CH2:9]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 183175566-(2-Chlorophenyl)-3-methyl-2-phenyl-4,5,6,7-tetrahydroindazol-4-oneHCID 178418668HCID 178418668, 화합물

생성물 1

HCID 1784216616-(2-Chlorophenyl)-4-guanidinoimino-3-methyl-2-phenyl-4,5,6,7-tetrahydroindazole hydrochloride수율 190.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 6-(2-chlorophenyl)-3-methyl-2-phenyl-4,5,6,7-tetrahydroindazol-4-one (0.6 g), aminoguanidine hydrochloride (0.24 g), concentrated hydrochloric acid (0.45 ml), water (0.45 ml) and ethanol (20 ml) was refluxed for 12 hours. Under reduced pressure, the solvent was evaporated, and the resulting crystals were recrystallized from ethanol-water to give 6-(2-chlorophenyl)-4-guanidinoimino-3-methyl-2-phenyl-4,5,6,7-tetrahydroindazole hydrochloride (Compound 150) (0.73 g) as colorless crystals.

후처리

  1. temperaturewas refluxed for 12 hours
  2. customUnder reduced pressure, the solvent was evaporated
  3. customthe resulting crystals were recrystallized from ethanol-water

출처 및 근거

ORD 기록
ord-50dde398f6c14ae9a54fe4281a8fce0f
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06350749B1

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