Acetone → 4-(2-Chloro-5-fluorophenyl)-3-buten-2-one
반응식
[OH-].[Na+].[Cl:3][C:4]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][C:5]=1[CH:6]=O.[CH3:13][C:14]([CH3:16])=[O:15]>O>[Cl:3][C:4]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][C:5]=1[CH:6]=[CH:13][C:14](=[O:15])[CH3:16]참가 물질
5
실험 절차
In water (55 ml) was dissolved sodium hydroxide (0.78 g), and to the mixture was added acetone (55 ml), and then added dropwise a solution of 2-chloro-5-fluorobenzaldehyde (2.8 g) in acetone (10 ml). The reaction solution was stirred at room temperature for 2 hours, and acetone was evaporated under reduced pressure. The residue was extracted with ethyl acetate, and the organic layer was washed with water and saturated brine, and concentrated under reduced pressure to give 4-(2-chloro-5-fluorophenyl)-3-buten-2-one (0.24 g).
후처리
- customacetone was evaporated under reduced pressure
- extractionThe residue was extracted with ethyl acetate
- washthe organic layer was washed with water and saturated brine
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-6fd708a4a92d4e519a67e8b4383bce2f
- 출처 데이터셋
- uspto-grants-2002_02
- 특허 번호
- US06350749B1
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