Ammonia → 1,3-Diphenylpropane-1,3-diamine

HRID 1701476노트

반응식

HRID 1701476 반응식
[C:1]1([C:7]2[CH2:11][CH:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N>[Ni].CO>[C:1]1([CH:7]([NH2:8])[CH2:11][CH:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[NH2:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 2

HCID 222AmmoniaHCID 36838443,5-diphenyl-4,5-dihydro-1H-pyrazole

생성물 1

HCID 868441,3-Diphenylpropane-1,3-diamine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

111 g (0.5 mol) of 3,5-diphenyl-2-pyrazoline are hydrogenated with 10 g of freshly prepared Raney nickel in 400 ml of methanol saturated with NH3 for 14 hours at 80° C./100 atmospheres. The catalyst is filtered off and the solvent is removed in a rotary evaporator. Distillation under a high vacuum gives 102 g=90% of theory of a colourless oil1/2.

후처리

  1. filtrationThe catalyst is filtered off
  2. customthe solvent is removed in a rotary evaporator
  3. distillationDistillation under a high vacuum
  4. customgives 102 g=90% of theory of a colourless oil1/2

출처 및 근거

ORD 기록
ord-1e1b7082371e4888a0003e0dfb6368ad
출처 데이터셋
uspto-grants-1980_03
특허 번호
US04193905

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